1. 重点关注生物医学传感器及智能仪器（医疗电子）领域，攻克生物标志物高灵敏度传感机制、微流控器件中微泵、微阀、微混合、浓度梯度、液滴、微针药物递送等关键微量流体控制技术。

2. 针对影响人类健康的各类疾病的早期体外诊断机制，开展无创、微创、便携式及可穿戴式个性化诊断的生物医学传感器及检测仪器的基础应用研究，以电子技术为基础，为疾病的精准诊断及治疗提供新技术、新手段。


3. 从生物医学传感器研制及检测方式的角度提出创新性研究，形成具有生物医学研究特色的知识产权积累，为相关研究技术落地实现科技转化奠定技术基础。

• 代表性研究成果和学术奖励情况：
  1. Zhengxian Dan; Huanhuan Shi*; Jiacong Liao; Xuanhao Jia;Zhiying Dai; Chenyang Xu; Spiral tumor cell particle inertial focusing device based on secondary flow structure enhancement, Physics of Fluids 37, 092023 (2025) (中科院二区)
  
  2. Weizheng Xu, Huanhuan Shi*, Shanqi Bao, Zidong Zhou, Ziwen Cheng, Chen Huang, Xinyi Wang, Shijie Qu, Electrochemical detection of cardiovascular diseases and treatment platform based on microfluidic technology, Microchimica Acta (2025) 192:807(中科院二区)
  
  3. Zidong Zhou, Huanhuan Shi*, Weizheng Xu, Shanqi Bao, Shijie Qu, Xinyi Wang, Ziwen Cheng, Chen Huang, Exosome separation and detection method based on microfluidic technology and its application in physiological fluids diagnosis, Microchemical Journal, 219 (2025) 116072(中科院二区)
  
  4. Yun Zheng, Huanhuan Shi*, Zhongjian Tan, Weizheng Xu, Zhengxian Dan, Jiacong Liao, Zhiying Dai et al., Portable electrochemical detection of salivary cortisol in self-driven microfluidic chip designed for trace liquid mixing, Chemical Engineering Journal 519 (2025) 165007 (中科院一区TOP)
  
  5. Yun Zheng, Huanhuan Shi*, Zhongjian Tan, Weizheng Xu, Rui Zhao, Zhengxian Dan，Zhiying Dai, Jiacong Liao, Hongwen Wu*,TrAC Trends in Analytical Chemistry, 2025, 118236. (中科院一区TOP)
  
  6. Weizheng Xu，Yu Cao，Huanhuan Shi*，Xuanhao Jia，Yun Zheng，Zhongjian Tan，Rui Zhao，Hongwen Wu，Talanta 291 (2025) 127895. (中科院一区TOP)
  
  7. Chenyang Xu（本科生）, Huanhuan Shi*,Zhongjian Tan,Yun Zheng, Weizheng Xu, Zhengxian Dan, Jiacong Liao,Zhiying Dai, Yali Zhao*,Generation, Manipulation, Detection and Biomedical Applications of Magnetic Droplets in Microfluidic Chips, Analyst, 2024, DOI: 10.1039/D4AN01175A(中科院三区)
  
  8. Zhongjian Tan, Yun Zheng, Huanhuan Shi*, Weizheng Xu, Xuanhao Jia, Zhengxian Dan, Jiacong Liao, Zhiying Dai, Chenyang Xu, Research progress and application exploration of typical microreactor technologies for health monitoring and disease Diagnosis/Treatment, Chemical Engineering Journal, 499, 2024, 155938. (中科院一区TOP)
  
  9. Zhongjian Tan, Huanhuan Shi*, Yun Zheng, Wen He, Weizheng Xu, Yu Cao, Jiacong Liao, Zhengxian Dan, Shuai Huang*, Application of Microreactor Constructed with Micro-Mixing Channel Featuring 3D Lateral Secondary Flow Structure for Ultra-small particle size Preparation of Magnetic Chitosan Nanodrug Carriers, Chemical Engineering Journal, 2024, 156040. (中科院一区TOP)
  
  10. Yun Zheng; Xunhao Jia（本科生）; Huanhuan Shi*；Solid-Phase microextraction on Self-Driven microfluidic chip using capillary micropump and microvalves for saliva electrochemical analysis, Microchemical Journal, 2024, 111579. (中科院二区TOP)
  
  11. Zhongjian Tan; Yuwei Yan（本科生）; Jiacong Liao（本科生）; Huanhuan Shi *; Yun Zheng; Weizheng Xu; Chen Yi; Zhiying Dai; Chenyang Xu, Droplet array with microfluidic concentration gradient (DA-MCG) for 2-dimensional reaction condition screening, Chemical Engineering Science 298 (2024) 120432 (中科院二区TOP)
  
  12. Cao Yu; Shi Huanhuan*; Yi Chen; Zheng Yun; Tan Zhongjian; Jia Xuanhao; Liu Zhengchun, Recent progress of non-invasive in vitro diagnosis using electrochemical analysis strategy and wearable microfluidic devices applied to exocrine secretion sampling, Trac-Trends in Analytical Chemistry, 2024, 172, 117561. (中科院一区TOP)
  
  13. Tan Zhongjian; Shi Huanhuan*; Cao Yu; Zheng Yun; A 3D Homogeneous Microreactor with High Mixing Intensity at Wide Re Range for MOF Preparation and POCT Application, Chemical Engineering Journal, 2023. 476, 146481 (中科院一区TOP，影响因子15.1)
  
  14. Shi Huanhuan*; Cao Yu; Xie Zhihao; Yan Yuwei; Zhang Congxuan; Chen Zhen*, Book Chapter: Ion-exchange membranes in microfluidic devices" in "Current Trends and Future Developments on (Bio-) Membranes", Elsevier.(参编专著)
  
  15. Cao Yu; Shi Huanhuan*; Zheng Yun; Tan Zhongjian; Xie Zhihao; Congxuan Zhang; Zhen Chen, Polyaniline/Prussian Blue Nanolayer Enhanced Electrochemical Sensing of H2O2 in EBC Using an Integrated Condensation Facemask, Sensors and Actuators: B-Chemical, 2023, 393, 134189. (中科院一区TOP，影响因子8.4)
  
  16. Shi Huanhuan*; Cao Yu; Zeng Yiming; Zhou Yanuo; Wen Weihua; Zhang Congxuan; Zhao Yali*; Chen Zhen*,Wearable tesla valve-based sweat collection device for sweat colorimetric analysis, Talanta, 2022, 123208. (中科院一区TOP，2022 ESI高被引，影响因子6.556)
  
  17. Shi Huanhuan*; Cao Yu; Xie Zhihao; Zhao Yali; Zhang Congxuan; Chen Zhen*, Multi-parameter photoelectric data fitting for microfluidic sweat colorimetric analysis, Sensors and Actuators: B-Chemical, 2022, 372: 132644. (中科院一区TOP，影响因子9.221)
  
  18. Shi, Huanhuan*; Zhao, Yali; Liu, Zhengchun, Numerical investigations of the secondary flow effect of lateral structure of micromixing channel on laminar flow. Sensors and Actuators B: Chemical, 2020, 321: 128503. (中科院一区TOP，影响因子9.221)
  
  19. Shi Huanhuan; Nie Kaixuan; Dong Bo; Chao Lemeng; Gao Fengxiao; Ma Mingyang; Long Mengqiu; Liu Zhengchun*, Mixing enhancement via a serpentine micromixer for real-time activation of carboxyl. Chemical Engineering Journal, 2020, 392(00): 0-123642. (中科院一区TOP，影响因子16.744)
  
  20. Shi, Huanhuan*; Xie, Zhihao; Cao, Yu; Zhao, Yali*; Zhang, Congxuan; Chen, Zhen*; Nuno M Reis; Liu, Zhengchun,A microfluidic serial dilutor (MSD): Design optimization and application to tuning of liposome nanoparticle preparation, Chemical Engineering Science, 2022, 263: 118080. (中科院二区TOP，影响因子4.889)
  
  21. Shi, Huanhuan*; Jiang, Shaofeng; Liu, Bo; Liu, Zhengchun*; Reis, Nuno M.*, Modern microfluidic approaches for determination of ions, Microchemical Journal, 2021, 171: 106845. (中科院二区，影响因子5.304)
  
  22. Yan, Yuwei (本科生); Shi, Huanhuan (指导教师); Zhao, Yali*; Cao, Yu;Xie, Zhihao, Correlation study of biomechanical changes between diabetic eye disease and glaucoma using finite element model of human eye with different iris-lens channel distances, Medical Engineering & Physics, 2022, 109: 103910. (中科院三区，影响因子2.356)
  
  23. Zhao Yali*; Hu Guohuang; Yan Yuwei; Wang Zhen; Liu Xiaohua; Shi, Huanhuan*,Biomechanical analysis of ocular diseases and its in vitro study methods, BioMedical Engineering OnLine, 2022, 21: 49. (中科院三区，影响因子3.903)
  
  24. Shi, Huanhuan; Nie, Kaixuan; Dong, Bo; Long, Mengqiu; Liu, Zhengchun*, Automatic in Situ Synthesis System for Polypeptide Biochip Based on Microfluidic Mixer, IEEE Transactions on NanoBioscience, 2021, 20(1): 116-125. (中科院三区，影响因子3.206)
  
  25. Shi, Huanhuan; Hou, Zhengli; Zhao, Yali; Nie, Kaixuan; Dong, Bo; Chao, Lemeng; Shang, Shenghong; Long, Mengqiu; Liu, Zhengchun*, Rapid and steady concentration gradient generation platform for an antimicrobial susceptibility test, Chemical Engineering Journal, 2019, 359: 1327-1338. (中科院一区TOP，影响因子16.744)
  
  26. Shi, Huanhuan; Nie, Kaixuan; Dong, Bo; Long, Mengqiu; Xu, Hui; Liu, Zhengchun*, Recent Progress of Microfluidic Reactors for Biomedical Applications Chemical Engineering Journal, 2019, 361: 635-650. (中科院一区TOP，影响因子16.744, 他引超130次)
  
  27. 石环环;曹禺;周亚诺;万亚茹;赵亚丽*, 微流控浓度梯度芯片的开发与生物化学应用研究, 中国医学物理学杂志, 2021, 38(10): 1299-1303.
  
  28. Shi, Huanhuan; Yang, Feipeng; Li, Wenjia; Zhao, Weiwei; Nie, Kaixuan; Dong, Bo; Liu, Zhengchun*, A review: Fabrications, detections and applications of peptide nucleic acids (PNAs) microarray,Biosensors and Bioelectronics, 2015, 66: 481-489.
  
  29. Shi, Huanhuan; Yang, Feipeng; Niu, Yanfang; Wu, Yanqi; Wang, Hongyin;Liu, Zhengchun*; Liang, Bo, Fluorescent Pyrene Assisted Photodeprotection of 2-(2-nitrophenyl)Propyloxyca rbonyl Groups on Self-Assembled Monolayers. Journal of Nanoscience and Nanotechnology, 2015, 15(4): 2650-2656.
  
  30. 发卡型寡聚酰胺对双链DNA的识别研究,李文佳;石环环;董波;刘正春, 生物医学工程学杂志, 2017, (01): 134-139.
  
  31. Diketopyrrolopyrrole-doped hybrid FONs as two-photon absorbing and dual-emission fluorescent nanosensors for Hg2+. Nie, Kaixuan; Xu, Shuai; Duan, Xiangyan; Shi, Huanhuan; Dong, Bo; Long, MengQiu; Xu, Hui; Jiang, Xiao Fang; Liu, Zhengchun*. Sensors and Actuators B: Chemical, 2018, 265: 1-9.
  
  32. Film-Spotting chiral miniPEG-gamma PNA array for BRCA1 gene mutation detection Dong, Bo; Nie, Kaixuan; Shi, Huanhuan; Chao, Lemeng; Ma, Mingyang; Gao, Fengxiao; Liang, Bo; Chen, Wei; Long, Mengqiu; Liu, Zhengchun*, Biosensors and Bioelectronics, 2019, 136: 1-7.
  
  33. N-alkylated diketopyrrolopyrrole-based ratiometric/fluorescent probes for Cu2 detection via radical process. Nie, Kaixuan; Dong, Bo; Shi, Huanhuan; Chao, Lemeng; Duan, Xiangyan; Jiang, Xiao Fang; Liu, Zhengchun*; Liang, Bo*, Dyes and Pigments, 2019, 160: 814-822.
  
  34. Pyridyl DPP based soluble nanoaggregates for ratiometric/fluorescent detection of Cu2 /Hg2 in water Nie, Kaixuan; Dong, Bo; Shi, Huanhuan; Chao, Lemeng; Huang, Zhongchao; Long, Mengqiu; Xu, Hui; Liu, Zhengchun*; Liang, Bo*, Journal of Luminescence, 2019, 208: 408-414.
  
  35. Light-Directed Synthesis of High-Density Peptide Nucleic Acid Microarrays Yang, Feipeng; Dong, Bo; Nie, Kaixuan; Shi, Huanhuan; Wu, Yanqi; Wang, Hongin; Liu, Zhengchun*. ACS Combinatorial Science, 2015, 17(10): 608-614.
  
  36. Thienyl diketopyrrolopyrrole as a robust sensing platform for multiple ions and its application in molecular logic system Nie, Kaixuan; Dong, Bo; Shi, Huanhuan; Liu, Zhengchun*; Liang, Bo* Sensors and Actuators B: Chemical, 2017, 244: 849-853.
  
  37. Synthesis and characterization of (R)-miniPEG-containing chiral gamma-peptide nucleic acids using the Fmoc strategy Dong, Bo;Nie, Kaixuan; Shi, Huanhuan; Yao, Xiaoxia; Chao, Lemeng; Liang, Bo; Liu, Zhengchun*. Tetrahedron Letters, 2019, 60(21): 1430-1433.
  
  38. Recognition Mechanisms and Applications of Peptide Nucleic Acids Targeting Double-stranded DNA Li, Wenjia; Shi, Huanhuan; Dong, Bo; Nie, Kaixuan; Liu, Zhengchun*; He, Nongyue*. Current Medicinal Chemistry, 2016, 23(41): 4681-4705.
  
  39. Spindle-shaped microfluidic chamber with uniform perfusion flows Wang, Hong Yin; Yang, Fei Peng; Wu, Yan Qi; Xu, You Zhi; Shi, Huanhuan; Liu, Jian Xin; Liu, Zheng Chun*. Microfluidics and Nanofluidics, 2013, 15(6): 839-845.
  
  40. Design, Synthesis, Properties, and Applications of Chiral Peptide Nucleic Acid Monomers Dong, Bo; Nie, Kaixuan; Shi, Huanhuan; Li, Wenjia; Liu, Zhengchun*. Current Organic Chemistry, 2016, 20(25): 2703-2717.
  
  41. Applications of Field Effect Transistor Biosensors Integrated in Microfluidic Chips Chao, Lemeng; Shi, Huanhuan; Nie, Kaixuan; Dong, Bo; Ding, Jiafeng; Long, Mengqiu; Liu, Zhengchun*. Nanoscience and Nanotechnology Letters, 2020, 12(4): 427-445.
  
  42. Design and Simulation of a Passive Micromixer with Gourd-Shaped Channel Hong Weiqin; Shi Huanhuan; Huang Z; Long M; Xu H; Liu Z. Journal of Nanoscience and Nanotechnology, 2019, 19(1): 206-212.
  
  43. 石环环; 戴智莹, 一种含涡流结构的微反应发生器，ZL202510781261.X
  
  44. 石环环; 但政贤, 一种螺旋结构惯性聚焦微流控细胞筛选装置及其筛选方法, ZL202411734947.5
  
  45. 石环环; 许炜铮, 一种穿戴式汗液实时检测装置及其检测方法, ZL202411571632.3
  
  46. 石环环; 郑昀，一种自驱动微混合芯片, ZL202411298204.8
  
  47. 石环环; 谭重鉴; 郑昀; 曹禺, 一种微反应器及制备纳米颗粒的方法, ZL 202310831206.8
  
  48. 石环环; 曹禺; 郑昀; 谭重鉴; 谢志豪，用于检测呼出气中生物标志物的纳米聚苯胺/普鲁士蓝电极、制备方法、装置及方法，ZL202310468295.4
  
  49. 石环环，谭重鉴，一种3D二次流结构，ZL2024 1 0647545.5
  
  50. 石环环，曹禺，一种采用多微流控浓度梯度芯片的药物自动筛选平台，ZL2024104240046
  
  51. 石环环，郑昀，一种基于整体柱富集分离的自驱动微流控系统，ZL2024100883982
  
  52. 刘正春（博士导师）；石环环，芘及其衍生物作为生物芯片制备中光敏基团脱保护增敏试剂的应用，发明专利授权，2015-07-22，中国，ZL201310168592.3.
  
  53. 刘正春（博士导师）；石环环，一种方波被动式微混合器，发明专利授权
  
  54. 刘正春（博士导师）；石环环，一种微流体细胞药物浓度梯度生成器，发明专利授权
  
  55. 一种生物芯片原位制备系统及其应用方法，刘正春；石环环；董波；梁波；朝乐蒙；龙孟秋，发明专利授权，2018-04-17，中国，CN201810343089.X.
  
  56. 一种生物芯片原位制备系统，刘正春；石环环；董波；梁波；朝乐蒙；龙孟秋，实用新型授权，2019-05-03，中国，ZL201820544011.X.
  
  57. 一种二维被动式微混合器, 刘正春；洪薇沁；石环环；龙孟秋；徐慧，实用新型授权，2019-03-01，中国，ZL201820829516.0.
  
  58. 一种用于低密度肽核酸阵列制备的装置，刘正春；石环环；彭斌；聂凯旋；李文佳；董波，实用新型授权，2016-01-13，中国，ZL201520693920.6.
  
  59. 一种基于迪恩涡二次流混合通道的微流控浓度梯度芯片，石环环；万亚茹；卢恩勇；周亚诺；张嘉豪，实用新型，授权，2020-11-20，中国，ZL202022704803.9.
  
  2025年江西省十佳研究生指导教师

• 2024/2025南昌航空大学十佳研究生 指导教师

• 研究生国家奖学金 (曹禺、谭重鉴、郑昀，许炜铮) 指导教师
  江西省创新创业项目 指导教师
  全国生物医学工程创新设计大赛 二、三等奖 指导教师
  江西省研究生创新课题，南昌航空大学研究生创新课题指导教师
  湖南省优秀硕士论文
  中南大学优秀硕士论文
  中南大学优秀毕业生
  硕士研究生国家奖学金
  博士研究生国家奖学金
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  

Chemical Engineering Journal，Acta Biomaterialia，Phyics of fluid，Analytica Chimica Acta，Fluid Dynamics & Materials Processing，Nanoscience and Nanotechnology Letters 等杂志审稿人，Biomed. Explora编委，Frontiers in Lab on a Chip Technologies客座编辑，南昌航空大学学报青年编委，Biomedical Engineering Frontier杂志 青年编委，Biomedical Engineering Horizon杂志 青年编委，中国医师协会临床工程师分会 青年委员，Scientific Reports杂志 编委  

欢迎仪器科学与技术、电子信息、仪器仪表工程、生物医学工程等交叉学科，包括分析化学，电子信息，电子技术，POCT, IVD等学科或方向的同学加入，尤其欢迎立志于针对医疗健康需求开发新型仪器，将研究成果实现转化而创业的志同道合的同学共同努力，无科研热情，不能全身心投入者非诚勿扰。

e-mail：shihuanhuancsu@126.com